Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity.

作者: H. Uri Saragovi , Véronique Guillemard

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摘要: … tumors but possesses major drawbacks, such as poor solubility and lack of tumor selectivity. … to an increase or an improvement of the armamentarium and selectivity of cytotoxic agents. …

参考文章(24)
C. N. Venkateshan, A. D. Van den Abbeele, A. I. Kassis, S. J. Adelstein, G. S. Eisenbarth, Janina Baranowska-Kortylewicz, S. Ito, R. C. Nayak, G. Mariani, Capping and internalization of a monoclonal antibody-surface antigen complex: a possible mode of interaction of monoclonal antibodies and tumor cells. Journal of nuclear biology and medicine. ,vol. 35, pp. 111- 119 ,(1991)
Mary L. Disis, Martin A. Cheever, HER-2/neu protein: a target for antigen-specific immunotherapy of human cancer. Advances in Cancer Research. ,vol. 71, pp. 343- 371 ,(1997) , 10.1016/S0065-230X(08)60103-7
X.-D. Yang, A. Jakobovits, Ping Wang, C. G. Davis, X.-C. Jia, J. R. F. Corvalan, Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Research. ,vol. 59, pp. 1236- 1243 ,(1999)
C E Chandler, L M Parsons, M Hosang, E M Shooter, A monoclonal antibody modulates the interaction of nerve growth factor with PC12 cells. Journal of Biological Chemistry. ,vol. 259, pp. 6882- 6889 ,(1984) , 10.1016/S0021-9258(17)39810-1
Sergei Maliartchouk, H. Uri Saragovi, Optimal Nerve Growth Factor Trophic Signals Mediated by Synergy of TrkA and p75 Receptor-Specific Ligands The Journal of Neuroscience. ,vol. 17, pp. 6031- 6037 ,(1997) , 10.1523/JNEUROSCI.17-16-06031.1997
S Maliartchouk, L Ivanisevic, A C Cuello, K Burgess, Y Feng, T Debeir, H U Saragovi, A designed peptidomimetic agonistic ligand of TrkA nerve growth factor receptors. Molecular Pharmacology. ,vol. 57, pp. 385- 391 ,(2000)
Naoto Itoh, Shin Yonehara, Ai Ishii, Minako Yonehara, Sei-Ichi Mizushima, Masazumi Sameshima, Atsushi Hase, Yoshiyuki Seto, Shigekazu Nagata, The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. ,vol. 66, pp. 233- 243 ,(1991) , 10.1016/0092-8674(91)90614-5
H.Uri Saragovi, Kalle Gehring, Development of pharmacological agents for targeting neurotrophins and their receptors Trends in Pharmacological Sciences. ,vol. 21, pp. 93- 98 ,(2000) , 10.1016/S0165-6147(99)01444-3
Wadih Arap, Renata Pasqualini, Erkki Ruoslahti, Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model Science. ,vol. 279, pp. 377- 380 ,(1998) , 10.1126/SCIENCE.279.5349.377