Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: a population-based study.
作者： Anne Ropponen , Reijo Sund , Seija Riikonen , Olavi Ylikorkala , Kristiina Aittomäki
DOI: 10.1002/HEP.21111
关键词:
摘要: Intrahepatic cholestasis of pregnancy (ICP) is a liver disorder, thought to be specific for and spontaneously resolve after delivery. Increased rates gallstone formation hepatitis C have previously been associated with ICP. However, there are no longitudinal studies determine its significance as an indicator subsequent or biliary diseases. In this retrospective cohort study cases controls we assessed the risk diseases in 21,008 women, 10,504 history ICP during years 1972-2000 (cases) normal (controls). Cases were matched age, time delivery, place The diagnoses disease traced from Finnish Hospital Discharge Register almost 100% coverage. Several found significantly higher incidence patients than controls. rate ratio was 3.5 (CI 1.6-7.6; P < .001), nonalcoholic cirrhosis 8.2 1.9-35.5; .05), gallstones cholecystitis 3.7 3.2-4.2; .001) pancreatitis 3.2 1.7-5.7; .001). conclusion, association several Some at development other severe chronic Contrary what has thought, follow-up may need considered these patients.
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