Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging

摘要: BACKGROUND AND PURPOSE: A number of parameters derived from dynamic contrast-enhanced MR imaging and separate histologic features have been identified as potential prognosticators in high-grade glioma. This study evaluated the relationships between MRI–derived glioblastoma multiforme. MATERIALS METHODS: Twenty-eight patients with newly presenting multiforme underwent preoperative (conventional T1 MRI). Parametric maps initial area under contrast agent concentration curve, transfer coefficient, estimate volume extravascular extracellular space, blood plasma were generated, enhancing fraction was calculated. Surgical specimens used to assess subtype graded (World Health Organization classification system) assessed for necrosis, cell density, cellular atypia, mitotic activity, overall vascularity scores. Quantitative assessment endothelial surface area, vascular a profile count made by using CD34 immunostaining. The histopathologic examined. RESULTS: High values coefficient associated presence frank necrosis (P = .005). space fibrillary pattern CONCLUSIONS: correlation activity is reported. Further work warranted establish how MRI relate more quantitative measurements, including markers proliferation measures growth factor expression.