Membrane Marker Analysis of ‘Lymphoid’ and Myeloid Blast Crisis in PH1 Positive (Chronic Myeloid) Leukemia

摘要: In addition to its diagnostic application, the Ph1 chromosome has been used as a clonal marker for analysing haemopoietic stem cell development in man (8, 29). During these clinical studies it become evident that presentation and course of CML is heterogeneous (reviewed refs. 24, 3, 1). The disease often progresses into myeloid blast crisis (which resembles acute leukaemia, AML) sometimes ‘lymphoid’ lymphoid ALL). It also observed recently some positive patients with involvement present thus simulate common ALL (20, 1, 15), but obvious frequent 15). Thus, this particular syndrome morphologically dissimilar leukaemic populations patient nevertheless carry same marker, chromosome) offers unique possibilities analyse interrelationship leukaemias their respective normal target cells.