Dual effect of erythropoietin on liver protection and regeneration after subtotal hepatectomy in rats

摘要: The only currently offered curative option for many patients with primary or secondary liver tumors is the resection of hepatic tumors. aim this study was to evaluate role recombinant human erythropoietin (rhEPO) in protection and regeneration after subtotal hepatectomy rats. Rats undergoing 70% received an intraperitoneal injection saline (control) rhEPO (4 U/g) 30 minutes prior resection. Liver function assessed by measurement international normalized ratio (INR) levels, injury serum alanine aminotransferase aspartate levels. Hepatic apoptosis intrahepatic caspase-3 activity morphological criteria. capacity remnant livers over 7 days regenerated liver/body weight ratio, immunohistochemistry markers cell proliferation (Ki-67) angiogenesis (von Willebrand factor), phosphorylated extracellular signal-regulated kinase signaling. Two 4 hepatectomy, significantly higher animals treated versus control group (P < 0.005). Serum enzymes INR levels on 2 post-hepatectomy were lower pretreated comparison No statistically significant difference noted activity, caspase-3, a terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay between hepatectomized groups. In rhEPO-pretreated group, mitotic index, Ki-67 von factor expression, day 0.05) group. conclusion, treatment may offer unique beneficial dual-function strategy immediately Transpl, 2010. © 2010 AASLD.