Lower Intraocular Oxygen Tension in Diabetic Patients: Possible Contribution to Decreased Incidence of Nuclear Sclerotic Cataract

作者: Nancy M. Holekamp , Ying-Bo Shui , David Beebe

DOI: 10.1016/J.AJO.2006.01.016

关键词:

摘要: Purpose To report intraocular oxygen tension in eyes of diabetic and nondiabetic patients. Design A prospective, interventional consecutive case series. Methods Oxygen was measured with an optical sensor patients who were undergoing vitrectomy. Before turning on the infusion fluid, two locations: adjacent to lens mid vitreous cavity. Results Fifty from 50 included study. Twenty-one 29 The mean significantly lower than (8.4 ± 0.7 mm Hg vs 10.7 0.8 Hg; P Conclusion Eyes have Because oxidative damage nucleus increased been associated nuclear sclerotic cataract, these findings may help explain recent reports apparent protective effect diabetes mellitus against cataract.

参考文章(58)
H Helbig, J P Hinz, M H Foerster, U Kellner, Oxygen in the anterior chamber of the human eye. German journal of ophthalmology. ,vol. 2, pp. 161- 164 ,(1993)
Renu A. Kowluru, Timothy S. Kern, Robert N. Frank, Bruce A. Berkowitz, Thomas C. Hohman, Manvi Prakash, Subnormal retinal oxygenation response precedes diabetic-like retinopathy. Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 2100- 2105 ,(1999)
R A Linsenmeier, L B Padnick, G A Lutty, R D Braun, J Ahmed, M A McRipley, D S McLeod, D L Hatchell, Retinal hypoxia in long-term diabetic cats. Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 1647- 1657 ,(1998)
D Y Yu, V A Alder, S J Cringle, The response of rat vitreal oxygen tension to stepwise increases in inspired percentage oxygen. Investigative Ophthalmology & Visual Science. ,vol. 31, pp. 2493- 2499 ,(1990)
Y Honda, H Sakaue, A Negi, Comparative study of vitreous oxygen tension in human and rabbit eyes. Investigative Ophthalmology & Visual Science. ,vol. 30, pp. 1933- 1937 ,(1989)
Ross D. Shonat, Oxygen Delivery to the Retina and Related Visual Pathology Advances in Experimental Medicine and Biology. ,vol. 510, pp. 249- 254 ,(2003) , 10.1007/978-1-4615-0205-0_41
E Stefansson, M L Wolbarsht, M B Landers rd, Increased retinal oxygen supply following pan-retinal photocoagulation and vitrectomy and lensectomy. Transactions of the American Ophthalmological Society. ,vol. 79, pp. 307- 334 ,(1981)
D L Hatchell, R L Novack, E Stefánsson, Vitrectomy prevents retinal hypoxia in branch retinal vein occlusion. Investigative Ophthalmology & Visual Science. ,vol. 31, pp. 284- 289 ,(1990)
RITA HILLER, ROBERT D. SPERDUTO, FRED EDERER, EPIDEMIOLOGIC ASSOCIATIONS WITH NUCLEAR, CORTICAL, AND POSTERIOR SUBCAPSULAR CATARACTS American Journal of Epidemiology. ,vol. 124, pp. 916- 925 ,(1986) , 10.1093/OXFORDJOURNALS.AJE.A114481
Juha Niinikoski, Thomas K. Hunt, Marcus Kwan, In Vivo Measurements of Oxygen Tension in the Cornea, Aqueous Humor, and Anterior Lens of the Open Eye Investigative Ophthalmology & Visual Science. ,vol. 11, pp. 108- 114 ,(1972)