Androgen modulation of luteinizing hormone secretion by female rat gonadotropes.

摘要: In the female, androgens can have negative and positive actions in regulation of LH, but it is not clear how they may function during reproductive cycle. Toward resolving these potentially conflicting roles for androgen, we used an vitro model preovulatory gonadotropes to examine effect proestrous levels testosterone (1.7 nm) or dihydrotestosterone (DHT; 0.7 on LH secretion response pulsatile GnRH (1 elevated extracellular K+ (54 mm). For female rat pituitary cells cultured 17β-estradiol (E2)-containing medium, androgen treatment 16 h, 4 inhibited secretory a pulse either by about 60% suppressed acute augmentation action 20 nm progesterone GnRH- K+-induced secretion. absence E2, DHT also decreased induced GnRH. DHT’s suppressive could be partially overcome with increased (200 removal progesterone...