Extra-esophageal GERD: clinical dilemma of epidemiology versus clinical practice.

摘要: Gastroesophageal reflux disease (GERD) is a common disorder. A significant percentage of patients with GERD may experience extra-esophageal manifestations, such as asthma, cough, and laryngitis. Epidemiologic studies consistently demonstrate strong associations between potential manifestations. However, randomized controlled evaluating the use proton-pump inhibitors for treatment have inconsistent results. In few shown improvement in objective measures, forced expiratory volume or peak flow. For chronic are all small not demonstrated consistent acid suppression. Even recent well-designed large study laryngitis no difference resolution symptoms Given examples from literature, current suppression controversial. Although has been case series, it studies. We offer explanations discrepancy epidemiologic lack response to therapy clinical trials.