Midazolams cardiac depressant effects and their lack of reversal by flumazenil in isolated rabbit hearts.
作者： TULUN OZTURK , YESIM TUNCOK , SULE KALKAN , HULYA GUVEN , GULCIN ARAN
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摘要: Abstract Midazolam is known to cause a dose-dependent increase and decrease in the contractile force of myocardium. Whether flumazenil can reverse these effects midazolam remains unclear. In this study, we determined cardiac counter effect on midazolam-induced myocardial depression isolated rabbit hearts. Rabbit hearts were perfused using Langendorff technique, left ventricle pressure heart rate measured by transducer ventricle. One set with increasing concentrations for 10 min, another concomitant flumazenil. Concentrations 5, 10, 20 50 μ m decreased significantly (P
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