Salivary caffeine concentrations are comparable to plasma concentrations in preterm infants receiving extended caffeine therapy
作者： Nicole R. Dobson , Xiaoxi Liu , Lawrence M. Rhein , Robert A. Darnall , Michael J. Corwin
DOI: 10.1111/BCP.13001
关键词:
摘要: Aims Caffeine concentrations in preterm infants are usually measured the blood. However, salivary assays may provide a valid and practical alternative. The present study explored validity clinical utility of caffeine as an alternative to blood developed novel plasma/salivary distribution model. Methods Paired plasma samples were obtained 29 infants. Salivary using commercially available collection system. Caffeine saliva determined high-performance liquid chromatography. A population pharmacokinetic (PK) model was NONMEM 7.3. Results The mean (± standard deviation) gestational age (GA) at birth weight 27.9 ± 2.1 weeks 1171.6 ± 384.9 g, respectively. Paired postmenstrual (PMA) 35.5 ± 1.1 weeks. range 9.5–54.1 μg ml−1, with difference (95% confidence interval) between −0.18 μg ml−1 (−1.90, 1.54). strongly correlated (Pearson's correlation coefficient = 0.87, P < 0.001). PK simultaneously described by three-compartment recirculation model. Current body weight, GA, PMA postnatal not significantly any parameter. Conclusions Salivary sampling provides easy, non-invasive method for measuring concentrations. correlate highly well
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