Synthesis and hydrolytic degradation of graft copolymers containing poly(lactic acid) side chains
作者： Valérie Langlois , Karine Vallee-Rehel , Jean Jacques Peron , Alain le Borgne , Michael Walls
DOI: 10.1016/S0141-3910(02)00042-3
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摘要: Abstract Graft copolymers were synthetized by radical copolymerization of poly( dl lactic acid) (PLA) methacrylate, a hydrolyzable macromonomer, and tert -butyl acrylate, hydrophobic monomer in order to obtain degradable polymers. Cast films have been immersed artificial sea water. The influence different parameters on the kinetics hydrolytic degradation examined, including acrylate/macromonomer molar ratio, nature PLA end group (acid or ester functionality), average length side chain ( Pn =7 10) temperature (20 37 °C). Immediately after immersion, clear changes film surface topography observed atomic force microscopy observations, due water diffusion. uptake is concentrated microdomains. was monitored appearance acid, pH variations SEC measurements. Their suitabilities for release bioactive agent (cuprous oxide) studied Inductively Coupled Plasma. results showed that increasing proportion acid units leads faster cuprous oxide correlated with PLA.
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