Relationship Between Maternal Arterial Wave Reflection, Microvascular Function and Fetal Growth in Normal Pregnancy

摘要: Please cite this paper as: Khan, Mires, MacLeod and Belch (2010). Relationship Between Maternal Arterial Wave Reflection, Microvascular Function Fetal Growth in Normal Pregnancy. Microcirculation17(8), 608–614. Abstract Objective:  In 50 normotensive pregnancies, we examined the relationship between fetal growth, arterial wave reflection, microvascular function at 22, 34 weeks gestation, six weeks postpartum. Methods:  reflection was determined by measuring augmentation index (AIx). Changes skin microcirculation to acetylcholine (ACh) sodium nitroprusside (SNP) were assessed using laser Doppler imaging. Results:  At 22 weeks, birth weight centile correlated with AIx adjusted for maternal age, MAP, heart rate timing of reflected (r = −0.363, p = 0.012), ACh responses (r = 0.317, p = 0.022). (r = −0.420, p = 0.003). 34 weeks, (r = −0.301, p = 0.048). borderline (r = −0.323, p = 0.074). postpartum, no significant correlations found centile, AIx, responses. SNP did not correlate or any time point. Conclusion:  During normal pregnancy, changes vascular might reflect important adaptations that are required facilitate growth. This highlighted present study findings a positive correlation endothelial negative reflection.