Wnt5a promotes epithelial-to-mesenchymal transition and metastasis in non-small-cell lung cancer.

作者: Biao Wang , Zhen Tang , Huiyuan Gong , Li Zhu , Xuegang Liu

DOI: 10.1042/BSR20171092

关键词:

摘要: A recent study indicated that high Wnt5a expression is associated with poor prognosis in non-small-cell lung cancer (NSCLC) patients; however, the underlying mechanism was not …

参考文章(30)
Guoying Zhang, Xinshan Ye, Dexin Ji, Huarong Zhang, Fujia Sun, Chunqing Shang, Ying Zhang, Erxi Wu, Fengfei Wang, Fei Wu, Huihui Tian, Xin Liu, Linlin Chen, Kun Liu, Yishan Wang, Hanchen Liu, Wenhua Zhang, Yukun Guan, Qinwen Wang, Xiaohang Zhao, Xiaochun Wan, Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives Oncotarget. ,vol. 5, pp. 8528- 8543 ,(2014) , 10.18632/ONCOTARGET.2336
Chenlin Lu, Xudong Wang, Huijun Zhu, Jian Feng, Songshi Ni, Jianfei Huang, Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer Oncotarget. ,vol. 6, pp. 24912- 24921 ,(2015) , 10.18632/ONCOTARGET.4701
Regalla Kumarswamy, Giridhar Mudduluru, Paolo Ceppi, Santoshi Muppala, Miroslaw Kozlowski, Jacek Niklinski, Mauro Papotti, Heike Allgayer, MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer International Journal of Cancer. ,vol. 130, pp. 2044- 2053 ,(2012) , 10.1002/IJC.26218
Maki Kanzawa, Shuho Semba, Shigeo Hara, Tomoo Itoh, Hiroshi Yokozaki, WNT5A is a key regulator of the epithelial-mesenchymal transition and cancer stem cell properties in human gastric carcinoma cells. Pathobiology. ,vol. 80, pp. 235- 244 ,(2013) , 10.1159/000346843
G T Lee, D I Kang, Y-S Ha, Y S Jung, J Chung, K Min, T H Kim, K H Moon, J M Chung, D H Lee, W-J Kim, I Y Kim, Prostate cancer bone metastases acquire resistance to androgen deprivation via WNT5A-mediated BMP-6 induction British Journal of Cancer. ,vol. 110, pp. 1634- 1644 ,(2014) , 10.1038/BJC.2014.23
Haiji Bo, Shuhui Zhang, Li Gao, Ying Chen, Jing Zhang, Xuejiao Chang, Minghua Zhu, None, Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells BMC Cancer. ,vol. 13, pp. 496- 496 ,(2013) , 10.1186/1471-2407-13-496
Xianhua Xu, Ping-Li Sun, Jun-Zhe Li, Sanghoon Jheon, Choon-Taek Lee, Jin-Haeng Chung, Aberrant Wnt1/β-catenin expression is an independent poor prognostic marker of non-small cell lung cancer after surgery. Journal of Thoracic Oncology. ,vol. 6, pp. 716- 724 ,(2011) , 10.1097/JTO.0B013E31820C5189
Tobias Pukrop, Claudia Binder, The complex pathways of Wnt 5a in cancer progression. Journal of Molecular Medicine. ,vol. 86, pp. 259- 266 ,(2008) , 10.1007/S00109-007-0266-2
N Kremenevskaja, R von Wasielewski, A S Rao, C Schöfl, T Andersson, G Brabant, Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene. ,vol. 24, pp. 2144- 2154 ,(2005) , 10.1038/SJ.ONC.1208370