Insights into mast cell functions in asthma using mouse models

摘要: Therapeutics targeting specific mechanisms of asthma have shown promising results in mouse models asthma. However, these successes not transferred well to the clinic or treatment sufferers. We suggest a reason for this incongruity is that mast cell-dependent responses, which may play an important role pathogenesis both atopic and non-atopic asthma, are key component most current models. Two reasons wild type mice have, contrast humans, negligible number cells localized smaller airways parenchyma, only protocols show reactions. The development cell-deficient reconstitution within opened up possibility generate with marked cells. In addition, engrafted distribution more similar humans. article we review highlight -independent responses respect airway hyperresponsiveness inflammation using cell-engrafted mice.