Acaulide, an Osteogenic Macrodiolide from Acaulium sp. H-JQSF, an Isopod-Associated Fungus

摘要: Acaulide (1), a macrodiolide with an unprecedented framework, was characterized along its shunt products—acaulones A (2) and B (3)—from the culture of Acaulium sp. H-JQSF associated isopod Armadillidium vulgare. The spiro-linked 14-, 6-membered cycles 1 arise likely from iterative intermolecular Michael addition reactions. Biological evaluation in prednisolone-induced osteoporotic zebrafish demonstrated that is antiosteoporotic at 0.4 2.0 μM.