Molecular characterization of transcription factors that bind to the cAMP responsive region of the substance P precursor gene. cDNA cloning of a novel C/EBP-related factor.
作者： R. Kageyama , Y. Sasai , S. Nakanishi
DOI: 10.1016/S0021-9258(18)98648-5
关键词:
摘要: A cAMP response element (CRE) plays an important role in the cAMP-mediated gene regulation. Several factors that recognize a CRE have been characterized, and it has shown they need either covalent modification by protein kinase or cofactor such as adenovirus Ela to function activator. In this study we show substance P precursor expression is regulated identify sequence its promoter region. We find novel factor ATF2 bind region containing of gene. The analysis indicates protein, designated CELF, significant homology C/EBP family proteins carboxyl-terminal part basic leucine zipper motif. Ubiquitous CELF suggests utilized various genes. Cell-free transcription analyses indicate constitutive transcriptional activator without apparent phosphorylation A. These results demonstrate multiple are responsible for control through
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