5 Sperm Nuclear Activation during Fertilization

摘要: The delivery of the paternal genome to egg is a primary goal fertilization. In preparation for this step, nucleus developing spermatozoon undergoes extensive morphological and biochemical transformations during spermatogenesis yield tightly compacted sperm nucleus. These modifications are essentially reversed As result, incorporated many steps in cytoplasm as it develops into male pronucleus. (1) loses its nuclear envelope, (2) nucleoprotein remodeling, (3) decondenses increases size, (4) becomes more spherical, (5) acquires new envelope., (6) functionally competent synthesize DNA RNA. changes coordinate with meiotic processing maternal chromatin, often result behaviors asynchronous chromatin. For example, eggs fertilized meiosis, while chromatin remains condensed. A model presented that suggests some reasons why puzzling behavior exists. Defects any processes attending pronuclear development infertility. New assisted reproductive technologies have been developed ensure so healthy embryo produced. An emerging challenge further characterize molecular mechanisms control link these causes human Further understanding basic process promises revolutionize our mystery beginning life.