Acute effect of furosemide on glomerular filtration rate in diastolic dysfunction.

摘要: We sought to evaluate the acute effect of furosemide on glomerular filtration rate (GFR) in subjects with diastolic dysfunction. An equal number documented dysfunction (DD) and healthy volunteers (controls) were enrolled underwent a baseline GFR measurement via plasma clearance technetium-99m-diethylenetriaminepentaacetic acid. Within three seven days baseline, study scheduled for second study, which was performed immediately after administration (20 mg orally 20 intravenously). There eight (8 males mean age 42 ± 7.8 years; 6 white, 2 Asian) (7 males, 1 female, 64.5 9.3 7 whites, African-American). significant post-furosemide decline volunteers, vs. 131.6 19.8 117 18.2 mL/min, respectively (p = 0.03), patients DD, post-furosemid...