Chemokines in acute respiratory distress syndrome.

摘要: A characteristic feature of all inflammatory disorders is the excessive recruitment leukocytes to site inflammation. The loss control in trafficking these cells contributes diseases. Leukocyte a well-orchestrated process that includes several protein families including large cytokine subfamily chemotactic cytokines, chemokines. Chemokines and their receptors are involved pathogenesis Acute lung injury clinically manifests as acute respiratory distress syndrome (ARDS) caused by an uncontrolled systemic response resulting from clinical events major surgery, trauma, multiple transfusions, severe burns, pancreatitis, sepsis. Systemic involves activation alveolar macrophages sequestered neutrophils lung. hallmarks ARDS hypoxemia, diffuse bilateral pulmonary infiltrates, normal intracardiac filling pressures. magnitude duration may ultimately determine outcome patients with ARDS. Recent evidence shows activated chemokines play key role expanding number antagonists chemokine for hold promise new medicines combat