Latex Antigens: Identification and Use in Clinical and Experimental Studies, Including Crossreactivity with Food and Pollen Allergens

摘要: Learning objectives The purpose of this review is to introduce the reader range latex allergens that have been identified by polypeptide sequencing. This knowledge important for assessment clinical hypersensitivity, including crossreactivity with food and aeroallergens. Data sources MEDLINE search relevant publications reviews from English medical literature since 1989. Results Of more than 150 polypeptides in natural rubber, 35 or can act as are recognized IgE antibodies sera latex-sensitive subjects. Complete partial amino acid sequence data now obtained 20 allergens, facilitated cloning genes development allergen-specific antibodies. In adults, hevein (Hev b6), rubber elongation factor b1) Hev b5 reported major while children spina bifida, particle proteins allergens. Although incomplete, finished products indicate number well diversity antigens limited compared allergen profile latex. Latex allows epitope mapping, which establishes molecular basis understanding between latex, food, Conclusion identification paving way studying immunoreactivity these proteins, other reagents detect measure anigen-specific responses will increase diagnostic specificity allergic reactions products.