Transcriptional adaptations following exercise in Thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy

摘要: Background Selection for exercise-adapted phenotypes in the Thoroughbred racehorse has provided a valuable model system to understand molecular responses exercise skeletal muscle. Exercise stimulates immediate early as well delayed during recovery, resulting return homeostasis and enabling long term adaptation. Global mRNA expression immediate-response period not previously been reported muscle following any species. Also, global gene changes equine have reported. Therefore, identify novel genes key regulatory pathways responsible adaptation we used equine-specific cDNA microarrays examine from cohort of horses (n = 8) at three time points (before exercise, immediately post-exercise, four hours post-exercise) single bout treadmill exercise.