Modulation of platelet aggregation in baboons: implications for mixed chimerism in xenotransplantation. I. The roles of individual components of a transplantation conditioning regimen and of pig peripheral blood progenitor cells.
作者： James Z. Appel , Ian P.J. Alwayn , Leo Buhler , Holly A. DeAngelis , Simon C. Robson
DOI: 10.1097/00007890-200110150-00020
关键词:
摘要: The induction of tolerance to pig antigens in primates may facilitate the development successful clinical xenotransplantation protocols. infusion mobilized porcine peripheral blood leukocytes (PBPCs, comprised approximately 2% progenitor cells) into splenectomized preconditioned baboons, intended induce mixed hematopoietic cell chimerism, however, results a severe thrombotic microangiopathy (TM) that includes pronounced thrombocytopenia. Because mechanisms responsible for this phenomenon are unclear, we have explored effects individual components conditioning regimen, therapeutic adjuncts, and PBPCs on platelet aggregation.
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