Resistance of Pseudomonas aeruginosa to antimicrobial drugs.

摘要: Publisher Summary The effectiveness of an anti-bacterial agent against strains Ps. aeruginosa is dependent on three main factors: (1) activity at the active site (preferably bactericidal), (2) penetration into site, and (3) resistance to enzymatic modification. Of effective compounds available now, β-lactam antibiotics, aminoglycosides, polymyxins are all bacteriocidal. Antibiotic in clinical isolates generally because presence chromosomal mediated genes determining synthesis enzymes that specifically modify inactivate antibiotics. A number new antipseudomonas antibiotics being developed. hold great promise their low toxicity. Biochemical studies substrate specificities aminoglycoside inactivating have revealed functional groups these important for enzyme recognition. lacking certain been synthesized such studies.