Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.

作者： Laurent Castéra , Brigitte Le Bail , Françoise Roudot-Thoraval , Pierre-Henri Bernard , Juliette Foucher

DOI: 10.1016/J.JHEP.2008.08.018

关键词:

摘要: Background/Aims To assess prospectively the accuracy of transient elastography (TE, FibroScan) for detection cirrhosis and oesophageal varices (OV) in chronic hepatitis C (CHC), as compared with currently available non-invasive methods (AST/ALT ratio (AAR), APRI, prothrombin index (PI), platelet count (PC), FibroTest (FT) Lok index). Methods All tests were performed day liver biopsy (LB), taken reference, 298 consecutive CHC patients (cirrhosis: 70; Child-Pugh A: OV: 25). Results TE had best diagnostic (AUROCs: 0.96 vs. FT 0.82, APRI 0.80, PC 0.79, PI 0.73, AAR 0.61, respectively; p Conclusions is most accurate method early (cut-off: 12.5kPa), other methods, but cannot replace endoscopy OV screening.

参考文章(50)

Leonard B. Seeff, Management and Treatment of Hepatitis C Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma. pp. 189- 198 ,(2004) , 10.1007/978-4-431-53977-3_18

Liver biopsy sampling in chronic viral hepatitis. Seminars in Liver Disease. ,vol. 24, pp. 89- 97 ,(2004) , 10.1055/S-2004-823103

Giada Sebastiani, Alfredo Alberti, Non invasive fibrosis biomarkers reduce but not substitute the need for liver biopsy World Journal of Gastroenterology. ,vol. 12, pp. 3682- 3694 ,(2006) , 10.3748/WJG.V12.I23.3682

Adrien Kettaneh, Patrick Marcellin, Catherine Douvin, Raoul Poupon, Marianne Ziol, Michel Beaugrand, Victor de Lédinghen, Features associated with success rate and performance of fibroscan measurements for the diagnosis of cirrhosis in HCV patients: A prospective study of 935 patients Journal of Hepatology. ,vol. 46, pp. 628- 634 ,(2007) , 10.1016/J.JHEP.2006.11.010

Arun J. Sanyal, Robert J. Fontana, Adrian M. Di Bisceglie, James E. Everhart, Michael C. Doherty, Gregory T. Everson, John A. Donovan, Peter F. Malet, Savant Mehta, Muhammad Y. Sheikh, Andrea E. Reid, Marc G. Ghany, David R. Gretch, the HALT-C Trial Group, The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis. Gastrointestinal Endoscopy. ,vol. 64, pp. 855- 864 ,(2006) , 10.1016/J.GIE.2006.03.007

Marianne Ziol, Adriana Handra-Luca, Adrien Kettaneh, Christos Christidis, Frédéric Mal, Farhad Kazemi, Victor de Lédinghen, Patrick Marcellin, Daniel Dhumeaux, Jean-Claude Trinchet, Michel Beaugrand, Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with chronic hepatitis C. Hepatology. ,vol. 41, pp. 48- 54 ,(2005) , 10.1002/HEP.20506

Francesco Vizzutti, Umberto Arena, Roberto G. Romanelli, Luigi Rega, Marco Foschi, Stefano Colagrande, Antonio Petrarca, Stefania Moscarella, Giacomo Belli, Anna Linda Zignego, Fabio Marra, Giacomo Laffi, Massimo Pinzani, Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis. Hepatology. ,vol. 45, pp. 1290- 1297 ,(2007) , 10.1002/HEP.21665

Anna S. F. Lok, Marc G. Ghany, Zachary D. Goodman, Elizabeth C. Wright, Gregory T. Everson, Richard K. Sterling, James E. Everhart, Karen L. Lindsay, Herbert L. Bonkovsky, Adrian M. Di Bisceglie, William M. Lee, Timothy R. Morgan, Jules L. Dienstag, Chihiro Morishima, , Predicting cirrhosis in patients with hepatitis C based on standard laboratory tests: Results of the HALT‐C cohort Hepatology. ,vol. 42, pp. 282- 292 ,(2005) , 10.1002/HEP.20772

Farhad Kazemi, Adrien Kettaneh, Gisèle N’kontchou, Emmanuel Pinto, Nathalie Ganne-Carrie, Jean-Claude Trinchet, Michel Beaugrand, Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices Journal of Hepatology. ,vol. 45, pp. 230- 235 ,(2006) , 10.1016/J.JHEP.2006.04.006

10.

B. Maharaj, W.P. Leary, A.D. Naran, R.J. Maharaj, R.M. Cooppan, D. Pirie, D.J. Pudifin, Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. The Lancet. ,vol. 327, pp. 523- 525 ,(1986) , 10.1016/S0140-6736(86)90883-4

Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.

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Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores.

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