High-Risk Human Papillomavirus Affects Prognosis in Patients With Surgically Treated Oropharyngeal Squamous Cell Carcinoma

摘要: Purpose Human papillomavirus (HPV) DNA tumors actively integrating the E6 and E7 oncogenes have a distinct biologic behavior resulting in more favorable prognosis. To which extent viral integration by itself, and/or associated wild-type (wt) TP53 status, functional p16 contribute to prognosis is unclear. Patients Methods clarify how presence of high-risk (HR) -HPV, TP53, p16INK4a status interact with clinical outcome, we considered retrospective series 90 consecutive oropharyngeal cancer patients treated primarily surgery. Results Seventeen (19%) showed integrated HPV 16 (HPV positive), wt all but two patients, normal 15 assessable expression 17 patients. Thirty-five (39%), whom were positive, harbored mutations. deletion null immunophenotype occurred 28 58 respectively, was similarly distributed both mutated (48% 82%...