Synthesis, characterization and DNA binding of the complexes of rare earth with phenanthroline and demethylcantharate

摘要: Abstract Three novel rare earth complexes, [Ln2(DCA)2(phen)2](NO3)2·6H2O (Ln(III)=Sm(III)(1), Er(III)(2), Yb(III)(3); DCA2−=demethylcantharate, 7-oxabicyclo[2.2.1] heptane-2,3-dicarboxylate, C8H8O52−; phen=1,10-phenanthroline, C12H8N2) were synthesized. The structures characterized by elemental analysis, molar conductance, IR and TGA. results suggested that the structural features of complexes were: in each DCA2−, one carboxylate group, as bidentate bridging connected two ions; other chelate group took part coordination with ion. And cyclic ether oxygen DCA2− nitrogen atoms phen coordination. probable number was seven. interaction DNA studied UV-spectra, fluorescence spectra viscosity measurements. Following increasing concentration DNA, UV absorption bands nearby 265 nm three appeared hypochromism red-shift phenomena. values binding constants Kb 1.89×105 L/mol (1), 3.54×104 (2) 3.83×104 (3). could quench EB-DNA system, equilibrium Ksq 1.72(1), 0.56(2) 1.09(3). relative steadily decreased complexes. So, we infer may partially insert into DNA. study agarose gel electrophoresis showed cleave plasmid process reaction through unclassical redox mechanism.