Crystal Structures, Interactions with Biomacromolecules and Anticancer Activities of Mn(II), Ni(II), Cu(II) Complexes of Demethylcantharate and 2-Aminopyridine
作者： Fan Zhang , Qiu-Yue Lin , Xiao-Liang Zheng , Ling-Ling Zhang , Qiong Yang
DOI: 10.1007/S10895-012-1078-5
关键词:
摘要: Three novel transition metal complexes (Hapy)2[M(DCA)2]·6H2O (M = Mn(II) (1), Ni(II) (2), Cu(II) (3); DCA demethylcantharate, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylate, C8H8O5; Hapy 2-aminopyridine acid, C5H7N2) were synthesized and characterized by elemental analysis, infrared spectra, thermogravimetric analysis X-ray diffraction. DNA binding properties of the investigated electronic absorption fluorescence spectra viscosity measurements. Results indicated could bind to through partial intercalation mode with constants Kb/(L·mol-1) 1.91 × 104 5.13 (2) 1.12 105 (3) at 298 K. Meanwhile, interactions BSA also studied spectra. The results suggested that quench static quenching KA/(L·mol-1) 1.44 106 1.14 107 2.98 (3). And main contribution was tryptophan residues BSA. antiproliferative activity test revealed showed more intense inhibition ratios against human hepatoma cells lines gastric cancer in vitro. Copper(II) complex possesses strongest ratio cells.
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