Yersinia pestis uses the Ail outer membrane protein to recruit vitronectin
作者： Sara Schesser Bartra , Yi Ding , L. Miya Fujimoto , Joshua G. Ring , Vishal Jain
DOI: 10.1099/MIC.0.000179
关键词:
摘要: Yersinia pestis, the agent of plague, requires Ail (attachment invasion locus) outer membrane protein to survive in blood and tissues its mammalian hosts. is important for both attachment host cells resistance complement-dependent bacteriolysis. Previous studies have shown that interacts with components extracellular matrix, including fibronectin, laminin heparan sulfate proteoglycans, complement inhibitor C4b-binding protein. Here, we demonstrate Ail-expressing Y. pestis strains bind vitronectin – a functions cell attachment, fibrinolysis inhibition system. The Ail-dependent recruitment resulted efficient cleavage by Pla (plasminogen activator protease). Escherichia coli DH5α expressing bound vitronectin, but not heat-treated vitronectin. ability directly was demonstrated ELISA using purified refolded nanodiscs.
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