Effects of Helicobacter pylori infection on gastric parietal cells and E-cadherin in Mongolian gerbils.
作者： Motonobu Murakami , Mayu Fukuzawa , Mika Yamamoto , Kanako Hamaya , Yuumi Tamura
DOI: 10.1254/JPHS.12191FP
关键词:
摘要: Atrophic gastritis caused by infection with Helicobacter pylori is characterized parietal cell loss, which a main risk factor for gastric cancer. Parietal cells play crucial role in the regulation of lineage maturation and proliferation units. Among classical cadherins, E-cadherin plays an important not only epithelial cell-cell connections, but also maintenance polarity glandular architecture proliferation. The aim this study to elucidate how are altered infection. We studied effects on mucosal 2 weeks after inoculation investigated relationship between loss amount Mongolian gerbils. number staining below isthmus were immunohistochemistry. It was shown that reduction intercellular preceded disappearance cells. glands where lost replaced mucus secreting without E-cadherin. These results suggest damaged massive leading deregulation morphology.
sci-hub.se 参考文章(37)
J. Kartenbeck, E. Schmid, W.W. Franke, B. Geiger, Different modes of internalization of proteins associated with adhaerens junctions and desmosomes: experimental separation of lateral contacts induces endocytosis of desmosomal plaque material. The EMBO Journal. ,vol. 1, pp. 725- 732 ,(1982) , 10.1002/J.1460-2075.1982.TB01237.X
So-Hyun Shin, Gyeong Hoon Kang, Seog-Yun Park, Nayoung Kim, Jae-Sung Ko, Aberrant CpG Island Hypermethylation in Pediatric Gastric Mucosa in Association With Helicobacter pylori Infection Archives of Pathology & Laboratory Medicine. ,vol. 135, pp. 759- 765 ,(2011) , 10.1043/2010-0140-OA.1
Carl R. Schmidt, Y.J. Gi, Trusharth A. Patel, Robert J. Coffey, R. Daniel Beauchamp, A. Scott Pearson, E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells Surgery. ,vol. 138, pp. 306- 312 ,(2005) , 10.1016/J.SURG.2005.06.007
Sander J.O. Veldhuyzen van Zanten, Michael F. Dixon, Adrian Lee, The gastric transitional zones: Neglected links between gastroduodenal pathology and Helicobacter ecology Gastroenterology. ,vol. 116, pp. 1217- 1229 ,(1999) , 10.1016/S0016-5085(99)70025-9
Derek C. Radisky, Dinah D. Levy, Laurie E. Littlepage, Hong Liu, Celeste M. Nelson, Jimmie E. Fata, Devin Leake, Elizabeth L. Godden, Donna G. Albertson, M. Angela Nieto, Zena Werb, Mina J. Bissell, Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability Nature. ,vol. 436, pp. 123- 127 ,(2005) , 10.1038/NATURE03688
T. Maretzky, K. Reiss, A. Ludwig, J. Buchholz, F. Scholz, E. Proksch, B. de Strooper, D. Hartmann, P. Saftig, ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 9182- 9187 ,(2005) , 10.1073/PNAS.0500918102
Vittorio Necchi, Maria Elena Candusso, Francesca Tava, Ombretta Luinetti, Ulderico Ventura, Roberto Fiocca, Vittorio Ricci, Enrico Solcia, Intracellular, Intercellular, and Stromal Invasion of Gastric Mucosa, Preneoplastic Lesions, and Cancer by Helicobacter pylori Gastroenterology. ,vol. 132, pp. 1009- 1023 ,(2007) , 10.1053/J.GASTRO.2007.01.049
Nermin Ali, Masanori Yoshizumi, Seiji Yano, Saburo Sone, Hideki Ohnishi, Keisuke Ishizawa, Yasuhisa Kanematsu, Koichiro Tsuchiya, Toshiaki Tamaki, The Novel Src Kinase Inhibitor M475271 Inhibits VEGF-Induced Vascular Endothelial-Cadherin and β-Catenin Phosphorylation but Increases Their Association Journal of Pharmacological Sciences. ,vol. 102, pp. 112- 120 ,(2006) , 10.1254/JPHS.FP0060357
Christiane Weydig, Anna Starzinski-Powitz, Gert Carra, Johannes Löwer, Silja Wessler, CagA-independent disruption of adherence junction complexes involves E-cadherin shedding and implies multiple steps in Helicobacter pylori pathogenicity Experimental Cell Research. ,vol. 313, pp. 3459- 3471 ,(2007) , 10.1016/J.YEXCR.2007.07.015
Richard M Peek, Jean E Crabtree, Helicobacter infection and gastric neoplasia The Journal of Pathology. ,vol. 208, pp. 233- 248 ,(2006) , 10.1002/PATH.1868