Aberrant CpG Island Hypermethylation in Pediatric Gastric Mucosa in Association With Helicobacter pylori Infection
作者： So-Hyun Shin , Gyeong Hoon Kang , Seog-Yun Park , Nayoung Kim , Jae-Sung Ko
关键词:
摘要: Abstract Context.—Helicobacter pylori infection is primarily acquired during childhood and persists throughout life in the absence of eradication with antibiotics. Helicobacter induces methylation promoter CpG island loci gastric epithelial cells. Thus, aberrant hypermethylation cells likely occurs early life, although there are no existing data supporting this notion. Objectives.—To identify whether pediatric stomach mucosa association H to compare profiles samples from adult tissues. Design.—We analyzed (n = 47) 38) for their status 12 using MethyLight assay compared number methylated genes levels individual between pylori–positive pylori–negative sample results a...
allenpress.com
archivesofpathology.org参考文章(26)
Peter A. Jones, Stephen B. Baylin, The fundamental role of epigenetic events in cancer Nature Reviews Genetics. ,vol. 3, pp. 415- 428 ,(2002) , 10.1038/NRG816
Reijo Salovaara, Lauri A. Aaltonen, Hidewaki Nakagawa, Edward W. Martin, Gerard J. Nuovo, Albert de la Chapelle, Emmanuel E. Zervos, Age-related hypermethylation of the 5' region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Research. ,vol. 61, pp. 6991- 6995 ,(2001)
J.-P. Issa, CpG-island methylation in aging and cancer. Current Topics in Microbiology and Immunology. ,vol. 249, pp. 101- 118 ,(2000) , 10.1007/978-3-642-59696-4_7
M. A. Hahn, T. Hahn, D.-H. Lee, R. S. Esworthy, B.-w. Kim, A. D. Riggs, F.-F. Chu, G. P. Pfeifer, Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Research. ,vol. 68, pp. 10280- 10289 ,(2008) , 10.1158/0008-5472.CAN-08-1957
Shuji Ogino, Takako Kawasaki, Mohan Brahmandam, Mami Cantor, Gregory J. Kirkner, Donna Spiegelman, G. Mike Makrigiorgos, Daniel J. Weisenberger, Peter W. Laird, Massimo Loda, Charles S. Fuchs, Precision and Performance Characteristics of Bisulfite Conversion and Real-Time PCR (MethyLight) for Quantitative DNA Methylation Analysis The Journal of Molecular Diagnostics. ,vol. 8, pp. 209- 217 ,(2006) , 10.2353/JMOLDX.2006.050135
Tomomitsu Tahara, Tomoyuki Shibata, Hiromi Yamashita, Masakatsu Nakamura, Daisuke Yoshioka, Masaaki Okubo, Ichiro Hirata, Tomiyasu Arisawa, Chronic nonsteroidal anti‐inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa Cancer Science. ,vol. 100, pp. 1192- 1197 ,(2009) , 10.1111/J.1349-7006.2009.01175.X
Jean-Pierre J. Issa, Yvonne L. Ottaviano, Paul Celano, Stanley R. Hamilton, Nancy E. Davidson, Stephen B. Baylin, Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon Nature Genetics. ,vol. 7, pp. 536- 540 ,(1994) , 10.1038/NG0894-536
Yasuhito Yuasa, Hiromi Nagasaki, Yoshimitsu Akiyama, Yutaka Hashimoto, Touichirou Takizawa, Kazuyuki Kojima, Tatsuyuki Kawano, Kenichi Sugihara, Kazue Imai, Kei Nakachi, DNA methylation status is inversely correlated with green tea intake and physical activity in gastric cancer patients International Journal of Cancer. ,vol. 124, pp. 2677- 2682 ,(2009) , 10.1002/IJC.24231
Satoshi Nishizuka, Teiichi Motoyama, Takayoshi Waki, Gen Tamura, Takashi Tsuchiya, Kiyoshi Sato, Promoter Methylation Status of E-Cadherin, hMLH1, and p16 Genes in Nonneoplastic Gastric Epithelia American Journal of Pathology. ,vol. 161, pp. 399- 403 ,(2002) , 10.1016/S0002-9440(10)64195-8
Gyeong Hoon Kang, Hyeon Joo Lee, Kyu Sang Hwang, Sun Lee, Jae-Hoon Kim, Jung-Sun Kim, Aberrant CpG Island Hypermethylation of Chronic Gastritis, in Relation to Aging, Gender, Intestinal Metaplasia, and Chronic Inflammation American Journal of Pathology. ,vol. 163, pp. 1551- 1556 ,(2003) , 10.1016/S0002-9440(10)63511-0