Circulating tumor markers: Predictors of incomplete cytoreduction and powerful determinants of outcome in pseudomyxoma peritonei

摘要: Background Incomplete cytoreduction (IC) is one of the main prognostic factor in pseudomyxoma peritonei (PMP). We evaluated ability preoperative Ca125, CEA, and Ca19-9 to predict IC prognosis PMP. Methods One hundred fifty-six cases elected candidate cytoreductive surgery hyperthermic intraperitoneal chemotherapy from 1996 2011 were included study. assessed the: (1) optimal cut-off values for circulating Tumor markers (CTM) predicting (residual disease >2.5 mm) using receiver-operating characteristics (ROC); (2) discriminant power CTM risk prediction models by calculating area under ROC curve (AUC-ROC); (3) factors Cox proportional-hazard model. Results Optimal cut-offs 125 U/ml 18 ng/ml 89 U/ml Ca19-9. The AUCs-ROC 0.76, 0.68, 0.69 Ca19-9, respectively. addition model that considered clinicopathological increased marginally AUC-ROC (0.80–0.84). Ca125 > 125 U/ml, Ca19-9 > 89 U/ml independently affected overall survival. Conclusions Preoperative CTMs reasonable but not perfect discriminators IC. Moreover, Ca125 new values, proven be strong overcome value extension histological subtype. J. Surg. Oncol. 2013;108:1–8. © 2013 Wiley Periodicals, Inc.