Elevated tumour markers are normalized in most patients with pseudomyxoma peritonei 7 days after complete tumour removal.

摘要: Aim Elevation of the preoperative tumour markers in pseudomyxoma peritonei (PMP) is common and a risk factor for recurrence. There has, however, been no documentation effect complete removal on levels after cytoreductive surgery (CRS) hyperthermic intraperitoneal chemotherapy (HIPEC). The aim study was to compare 7 days patients with elevated levels. Method This an observational prospective PMP appendiceal origin treated one UK National Referral Centres this condition. Thirty [median age = 61 (range: 31–74) years; six men] level carcinoembryonic antigen (CEA), carbohydrate 125 (CA-125) and/or 19-9 (CA19-9) underwent repeated estimation, CRS HIPEC PMP. Results The median CEA 12 μg/l fell 0.75 μg/l postoperatively (P < 0.0001), CA-125 from 45 31 kU/l (P = 0.183) CA19-9 134 37 kU/l (P = 0.003). raised 22 (73%) 30 preoperatively two (7%) (P < 0.0001). corresponding data were 18 (60%) 13 (43%) (P = 0.196) they 24 (80%) 16 (53%) (P = 0.028). Conclusion This first reduction or normalization CRS, but not CA-125. This may indicate completeness surgical resection could aid selection adjuvant therapy predict prognosis. Long-term follow-up is, necessary determine significance observation.