Compensatory growth of porcine right lungs after chronic rejection of transplanted left lungs

摘要: Neonatal lung hypoplasia is frequently a fatal condition often associated with congenital diaphragmatic hernia. Unilateral transplantation rarely has been performed for this indication, although it potential solution. It not known whether the transplant needs to function permanently or act as bridge until native develops. also will grow in face of an immunosuppressed state and chronic rejection transplanted lung. We therefore developed porcine model left study this. Infant swine underwent transplantation. Chronic occurred all, resulting nonfunction The right lungs these animals were compared size-matched age-matched control given immunosuppressive treatment undergoing There no differences terms functional residual capacity, airway compliance, resistance among groups. was significant increase pulmonary vascular lungs. weight animals. pneumonectomies done 4 infant pigs serve controls. Three did survive operation because acute failure. In conclusion, group exhibited evidence compensatory growth that seen animals, shown by weight. This suggests contralateral occurs growing animal, despite effects immunosuppression therapy