Analysis of airway function of immature whole lung transplants versus mature lobar transplants

摘要: For the pediatric patient with end-stage lung disease in need of transplantation, two potential donor options currently exist: size-matched immature whole lungs or reduced-size mature lobes. To determine which these provides superior long-term function, we studied airway mechanics a chronic porcine model transplantation. Three groups animals were studied: first group underwent left upper lobectomy at 9 +/- 1 weeks age (innervated lower lobes). These served as controls. A second 9-week-old received an allograft from age-matched donors. The third lobe 6-month-old Measurements dynamic resistance, pulmonary compliance, and functional residual capacity isolated lobes lungs, nonoperated right recorded 12 later, mean values calculated for each group. Results showed that transplantation resulted abnormal resistance to airflow, was not seen lobar transplants. In addition, compliance impaired most significantly We conclude this experimental segment results function when compared