RNA interference-mediated silencing of NANOG leads to reduced proliferation and self-renewal, cell cycle arrest and apoptosis in T-cell acute lymphoblastic leukemia cells via the p53 signaling pathway.
作者： Jiang Cao , Li Li , Chong Chen , Chao Lv , Fanjing Meng
DOI: 10.1016/J.LEUKRES.2013.04.021
关键词:
摘要: NANOG is critical for maintaining the self-renewal and proliferative properties of embryonic stem cells. Here we found that cultured T-cell acute lymphoblastic leukemia (T-ALL) cells, as well human primary T-ALL express a functional variant NANOG. mRNA derived predominantly from retrogene locus termed NANOGP8. Furthermore, showed RNA interference-mediated knockdown inhibited cell proliferation, reduced self-renewal, promoted apoptosis arrested cycle through p53-mediated pathway in leukemic These findings demonstrate oncogenic potential this pluripotent gene
sci-hub.se 参考文章(51)
Peter Marynen, Kim De Keersmaecker, Jan Cools, Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia. Haematologica. ,vol. 90, pp. 1116- 1127 ,(2005) , 10.3324/%X
C R Jeter, B Liu, X Liu, X Chen, C Liu, T Calhoun-Davis, J Repass, H Zaehres, J J Shen, D G Tang, NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation Oncogene. ,vol. 30, pp. 3833- 3845 ,(2011) , 10.1038/ONC.2011.114
T Maimets, I Neganova, L Armstrong, M Lako, Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells. Oncogene. ,vol. 27, pp. 5277- 5287 ,(2008) , 10.1038/ONC.2008.166
Xin Zhang, Irina Neganova, Stefan Przyborski, Chunbo Yang, Michael Cooke, Stuart P. Atkinson, George Anyfantis, Stefan Fenyk, W. Nicol Keith, Stacey F. Hoare, Owen Hughes, Tom Strachan, Miodrag Stojkovic, Philip W. Hinds, Lyle Armstrong, Majlinda Lako, A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A Journal of Cell Biology. ,vol. 184, pp. 67- 82 ,(2009) , 10.1083/JCB.200801009
Tongxiang Lin, Connie Chao, Shin'ichi Saito, Sharlyn J. Mazur, Maureen E. Murphy, Ettore Appella, Yang Xu, p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression Nature Cell Biology. ,vol. 7, pp. 165- 171 ,(2005) , 10.1038/NCB1211
Matthieu Schoenhals, Alboukadel Kassambara, John De Vos, Dirk Hose, Jérôme Moreaux, Bernard Klein, Embryonic stem cell markers expression in cancers. Biochemical and Biophysical Research Communications. ,vol. 383, pp. 157- 162 ,(2009) , 10.1016/J.BBRC.2009.02.156
Feng Ye, Caiyun Zhou, Qi Cheng, Jiajie Shen, Huaizeng Chen, Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells BMC Cancer. ,vol. 8, pp. 108- 108 ,(2008) , 10.1186/1471-2407-8-108
Matthew P. McCormack, Terence H. Rabbitts, Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency The New England Journal of Medicine. ,vol. 350, pp. 913- 922 ,(2004) , 10.1056/NEJMRA032207
Leonardo Mirandola, Paola Comi, Everardo Cobos, W. Martin Kast, Maurizio Chiriva-Internati, Raffaella Chiaramonte, Notch-ing from T-cell to B-cell lymphoid malignancies. Cancer Letters. ,vol. 308, pp. 1- 13 ,(2011) , 10.1016/J.CANLET.2011.05.009
Jueng Soo You, Jae Ku Kang, Dong-Wan Seo, Jae Hyun Park, Jong Woo Park, Jae Cheol Lee, Yae Jee Jeon, Eun Jung Cho, Jeung-Whan Han, Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: involvement of Nanog suppression. Cancer Research. ,vol. 69, pp. 5716- 5725 ,(2009) , 10.1158/0008-5472.CAN-08-4953