Evaluation of potential mechanisms of atrazine-induced reproductive impairment in fathead minnow (Pimephales promelas) and Japanese medaka (Oryzias latipes).

摘要: Atrazine has been implicated in reproductive dysfunction of exposed organisms, and previous studies documented decreased egg production Japanese medaka (Oryzias latipes) fathead minnows (Pimephales promelas) during 30-d to 38-d exposures 0.5 µg/L, 5 µg/L, 50 µg/L atrazine. The authors evaluated possible mechanisms underlying the reduction production. Gene expression steroidogenesis pathways hypothalamus-pituitary-gonad axis male female fish was measured. did not significantly induce gonad aromatase (cyp19a1a) expression. An atrazine-induced shift number females an active state observed. Expression maturation genes vitellogenin 1 (vtg1) zona pellucida glycoprotein 3.1 (zp3.1) correlated had a bimodal distribution. In both species, with low vtg1 or zp3.1 also gonad, estrogen receptor liver, gonadotropins brain. medaka, per tank that high tank. increased atrazine exposure. Thus, decline observed response exposure may be result coordinated downregulation required for reproduction subset females. Environ Toxicol Chem 2016;35:2230-2238. Published 2016 Wiley Periodicals Inc. on behalf SETAC. This article is US Government work and, as such, public domain United States America.