Assessment of food toxicology

摘要: Abstract The interest in food toxicology is evident by the dependency of humankind on nutrition virtue their heterotrophic metabolism. By means modern biochemistry, molecular and cell biology, computer science, bioinformatics as well high-throughput high-content screening technologies it has been possible to identify adverse effects characterize potential toxicants food. mechanisms toxicant actions are multifactorial but many toxic converge generation oxidative stress chronic inflammation resulting death, aging degenerative diseases. Integration data obtained throughout biochemical cell-based vitro, animal vivo human clinical settings enabled establishment alternative, highly predictable silico models. These systems utilize a combination complex vitro models with computer-based algorithms. A decrease rodent testing its limitations high costs, low throughput readouts, inconsistent responses, ethical issues concerns extrapolability humans have led an increased use these also alternative lower hierarchy surrogate (e.g. Drosophila melanogaster; Caenorhabditis elegans or Danio rerio) efforts integrate organotypic stem assays. Despite those achievements, there numerous challenges various disciplines toxicology.