Prognostic value of Ki-67 expression in conversion therapy for colorectal liver-limited metastases.

摘要: Introduction: The objective of this study was to examine the prognostic value Ki-67 expression in conversion therapy for colorectal liver-confined metastases. Methods: We enrolled a total 96 patients including 54 who received oxaliplatin- or irinotecan-based chemotherapy and curative hepatectomy initially unresectable metastases (conversion group) 42 with resectable liver (straight group). examined resected specimens but excluded 2 that revealed no residual cancer cells group. Results: Conversion leads greater survival is equivalent straight In group, high (> 30%) levels were detectable 33 (64%) after prior therapy. High significantly associated shorter disease-free worse overall (P < 0.01 both), an independent factor (hazard ratio [HR] P-values 5.608, 0.001 5.366, 0.04, respectively) Interestingly, even RECIST PR (n = 32), compared low 0.001). contrast there significant difference disease free between 14, 33%) 28, 67%) expressions 0.14 0.74, respectively). Conclusions: Residual useful biomarker outcomes may be micrometastases containing aggressive cells.