Carcinoembryonic antigen transgenic mouse models for immunotherapy and development of cancer vaccines.

摘要: The goal of cancer therapy remains as the long-term eradication tumor cells without adverse effects on normal tissue. Conventional approaches utilizing chemotherapy and radiotherapy are limited by both their toxicity lack specificity. In recent years, investigators have carried out several studies designed to evaluate whether human tumor-associated antigens (TAAs) can be exploited targets for immunotherapy, specifically vaccine development. A major limitation in immunotherapy is general appropriate preclinical models. Clinical difficult implement, particularly when a clear understanding potential efficacy, limitation, safety an immunotherapeutic strategy not available from relevant animal investigations. However, mice carrying transgene self-antigen may provide more acceptable experimental model which knowledge about strategies aiming at TAA interest enhanced prior initiating clinical trials. Since different been directed activate immune system components, variety transgenic mouse models generated expressing either TAA, leukocyte antigen (HLA), oncogene, or effector cell molecules. These serve excellent platform identification novel well efficacy targeted therapies will lead development trials patients. this unit, brief overview generation study carcinoembryonic (CEA) findings that spontaneously develop gastrointestinal tumors express CEA provided.