Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the IRE1α Pathway Controls Lipid Metabolism in Mouse Liver
作者： Gaspard Cretenet , Mikaël Le Clech , Frédéric Gachon
DOI: 10.1016/J.CMET.2009.11.002
关键词:
摘要: Summary The mammalian circadian clock plays a fundamental role in the liver by regulating fatty acid, glucose, and xenobiotic metabolism. Impairment of this rhythm has been shown to lead diverse pathologies, including metabolic syndrome. Currently, it is supposed that regulates metabolism mostly expression enzymes at the transcriptional level. Here, we show also controls hepatic synchronizing secondary 12 hr period characterized rhythmic activation IRE1α pathway endoplasmic reticulum. absence perturbs and provokes deregulation reticulum-localized enzymes. This leads impaired lipid metabolism, resulting aberrant sterol-regulated SREBP transcription factors. mice devoid could be involved appearance associated
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