High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study.

摘要: We report results of a pilot study high-dose vitamin D in sickle cell disease (SCD). Subjects were followed for 6 months after receiving six-week course oral cholecalciferol or placebo. Vitamin insufficiency and deficiency was present at baseline 82.5% 52.5% subjects, respectively. who received achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, had physical activity quality-of-life scores. These findings suggest potential benefit reducing the number SCD. Larger prospective studies with longer duration are needed to confirm these effects.