Serum sFas/sFasL ratio in systemic lupus erythematosus (SLE) is a function of age.
作者： M.C. Turi , M. D’urbano , E. Celletti , C. Alessandri , G. Valesini
DOI: 10.1016/J.ARCHGER.2009.09.032
关键词:
摘要: Fas and ligand (FasL), members of the tumor necrosis factor (TNF) TNF-receptor (TNFR) families molecules, are involved in apoptosis. They expressed membrane-associated as well soluble forms (sFas, sFasL). Apoptotic defects underlie some models autoimmune diseases, they have been proposed pathogenesis systemic lupus erythematosus (SLE) a prototypic disorder. We measured serum levels sFas sFasL series characterized SLE patients devised an index two which resulted to be associated with age, indicating that apoptosis resistance is modulated during aging, thus explaining conflicting observations made previous studies.
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Marta Christensson, Erna Pettersson, Kjell Eneslätt, Birger Christensson, Johan Bratt, Solbritt Rantapää-Dahlqvist, Karl-Gösta Sundqvist, Serum sFAS Levels Are Elevated in ANCA-Positive Vasculitis Compared with Other Autoimmune Diseases Journal of Clinical Immunology. ,vol. 22, pp. 220- 227 ,(2002) , 10.1023/A:1016040925295
Noboru Suzuki, Motohide Ichino, Shoji Mihara, Sakae Kaneko, Tsuyoshi Sakane, Inhibition of Fas/Fas ligand-mediated apoptotic cell death of lymphocytes in vitro by circulating anti-Fas ligand autoantibodies in patients with systemic lupus erythematosus Arthritis & Rheumatism. ,vol. 41, pp. 344- 353 ,(1998) , 10.1002/1529-0131(199802)41:2<344::AID-ART19>3.0.CO;2-J
Yoshiaki Tokano, Sachiko Miyake, Nobuhiko Kayagaki, Kazuhisa Nozawa, Shinji Morimoto, Miyuki Azuma, Hideo Yagita, Yoshinari Takasaki, Ko Okumura, Hiroshi Hashimoto, Soluble Fas molecule in the serum of patients with systemic lupus erythematosus Journal of Clinical Immunology. ,vol. 16, pp. 261- 265 ,(1996) , 10.1007/BF01541390
M. Sahin, O. Aydıntug, S.E. Tunc, H. Tutkak, M. Nazıroğlu, Serum soluble Fas levels in patients with autoimmune rheumatic diseases. Clinical Biochemistry. ,vol. 40, pp. 6- 10 ,(2007) , 10.1016/J.CLINBIOCHEM.2006.09.003
F Silvestris, D Grinello, M Tucci, P Cafforio, F Dammacco, Enhancement of T cell apoptosis correlates with increased serum levels of soluble Fas (CD95/Apo-I) in active lupus Lupus. ,vol. 12, pp. 8- 14 ,(2003) , 10.1191/0961203303LU250OA
Kazuhisa Nozawa, Nobuhiko Kayagaki, Yoshiaki Tokano, Hideo Yagita, Ko Okumura, Hiroshi Hasimoto, Soluble Fas (APO-1, CD95) and soluble Fas ligand in rheumatic diseases. Arthritis & Rheumatism. ,vol. 40, pp. 1126- 1129 ,(1997) , 10.1002/ART.1780400617
Jia Hu Hao, Dong Qing Ye, Guo Qing Zhang, Hui Hui Liu, Hong Dai, Fen Huang, Fa Ming Pan, Hong Su, Ma Xia Dong, Hong Chen, Qian Wang, Xue Jun Zhang, Elevated levels of serum soluble Fas are associated with organ and tissue damage in systemic lupus erythematosus among Chinese. Archives of Dermatological Research. ,vol. 297, pp. 329- 332 ,(2006) , 10.1007/S00403-005-0616-2
Ahmed Sheriff, Udo S Gaipl, Reinhard E Voll, Joachim R Kalden, Martin Herrmann, Apoptosis and systemic lupus erythematosus Rheumatic Diseases Clinics of North America. ,vol. 30, pp. 505- 527 ,(2004) , 10.1016/J.RDC.2004.04.006
Melissa R. Arbuckle, Micah T. McClain, Mark V. Rubertone, R. Hal Scofield, Gregory J. Dennis, Judith A. James, John B. Harley, Development of autoantibodies before the clinical onset of systemic lupus erythematosus. The New England Journal of Medicine. ,vol. 349, pp. 1526- 1533 ,(2003) , 10.1056/NEJMOA021933
E. Tinazzi, A. Puccetti, R. Gerli, A. Rigo, P. Migliorini, S. Simeoni, R. Beri, M. Dolcino, N. Martinelli, R. Corrocher, C. Lunardi, Serum DNase I, soluble Fas/FasL levels and cell surface Fas expression in patients with SLE : a possible explanation for the lack of efficacy of hrDNase I treatment International Immunology. ,vol. 21, pp. 237- 243 ,(2009) , 10.1093/INTIMM/DXN142