MicroRNA Networks in Breast Cancer Cells.

摘要: A variety of molecular techniques can be used in order to unravel the composition cells. In particular, microarray technology has been identify novel biomarkers that may useful diagnosis, prognosis, or treatment cancer. The is ideal for biomarker discovery as it allows screening a large number molecules at once. this review, we focus on microRNAs (miRNAs) which are key cells and regulate gene expression post-transcriptionally. miRNAs small, single-stranded RNA bind complementary mRNAs. Binding mRNAs leads either degradation, translational inhibition target mRNA. Roughly one third all postulated regulated by miRNAs. known deregulated different types cancer, including breast demonstrated deregulation several biological markers miRNA example discriminate between normal, benign malignant tissue, cancer subtypes.In post-genomic era, an important task biology understand regulation context networks. Because have such pronounced role cells, pivotal mechanisms underlie their control, how influence development progression.