Engineering tumors: a tissue engineering perspective in cancer biology.
作者： Emily Burdett , F. Kurtis Kasper , Antonios G. Mikos , Joseph A. Ludwig
DOI: 10.1089/TEN.TEB.2009.0676
关键词:
摘要: There is increasing recognition that three-dimensional (3D) tissue culture technologies have many uses within the biomedical sciences beyond scope of regenerative medicine. One such use in field cancer biology, where a 3D tumor model accurately recreates vivo phenotype would be valuable tool for studying biology and allow better preclinical evaluation anticancer drug candidates. The most widely used involves small cellular aggregates, termed spheroids, which been by biologists decades consistently shown superiority over standard two-dimensional monolayer mimicking behavior resistance encountered vivo. Currently, several research groups begun to adapt more advanced techniques from engineering create clinically accurate ex biology.
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