Melatonin as pharmacologic support in burn patients: a proposed solution to thermal injury-related lymphocytopenia and oxidative damage.

摘要: Objective: To review the data that support clinical use of melatonin in treatment burn patients, with special emphasis on stimulation oxidative defense system, immune circadian rhythm sleep/wakefulness, and reduction toxicity therapeutic agents used victims. Data Source: A MEDLINE/PubMed search from 1975 to July 2006 was conducted. Study Selection: The screening literature examined using key words: lymphocytopenia, skin stress, antioxidant, melatonin, free radicals. Extraction Synthesis: Thermal injury often causes damage multiple organs remote original wound may lead organ failure. Animal models patients exhibit elevated radical generation be causative local response development shock distant injury. suppression nonspecific resistance disturbance adaptive system makes vulnerable infections. Moreover, there is loss sleep produced by drugs habitually clinic for patients. Melatonin a powerful antioxidant potent protective agent against after experimental thermal Some actions as potential supportive pharmacologic include its: role scavenger both oxygen nitrogen-based reactants, activities variety antioxidative enzymes, proinflammatory cytokines, inhibition adhesion molecules, chronobiotic effects, protocols treat Conclusions: These combined along its low ability penetrate all morphophysiologic membranes, could make it ubiquitously acting highly beneficial molecule (Crit Care Med 2007;