Post-translational buffering leads to convergent protein expression levels between primates.

摘要: Differences in gene regulation between human and closely related species influence phenotypes that are distinctly human. While is a multi-step process, the majority of research concerning divergence among primates has focused on transcription. To gain comprehensive view regulation, we surveyed genome-wide ribosome occupancy, which reflects levels protein translation, lymphoblastoid cell lines derived from human, chimpanzee, rhesus macaque. We further integrated messenger RNA level measurements collected matching lines. find that, addition to transcriptional major factor determining post-translational buffering. Inter-species transcription generally propagated translation. In contrast, expression often attenuated post-translationally, potentially mediated through modifications. Results our analysis indicate buffering conserved mechanism led relaxation selective constraint transcript humans.