Insight into the biological properties and phytochemical composition of Ballota macrodonta Boiss. et Balansa, — an endemic medicinal plant from Turkey

摘要: Abstract Ballota macrodonta Boiss. et Balansa., is a traditionally used endemic medicinal plant to manage plethora of diseases in Turkey. Nonetheless, few studies have endeavoured highlight its therapeutic potential and phytochemical profile. We hypothesized that B. would possess multi-pharmacological propensities bioactive compounds justify use as folk remedy. Aerial part was assessed for antioxidant, antimicrobial, enzymatic inhibitory using different extraction solvents. The total components determination compound identification High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD) method were correlate the biological properties. HPLC-DAD profile showed presence 19 (e.g. hydroxybenzoic acid, catechin hydrate, vanillic caffeic syringic epicatechin, coumaric ferulic luteolin-7-O-glucoside, rutin, quercetin). water methanolic extracts high phenolic flavonoid contents, respectively. overall antioxidant capacity extract higher than one methanol extract. activity against cholinesterases, tyrosinase, α-amylase α-glucosidase. also presented antimicrobial eight Gram positive/negative bacteria (MIC – 0.05–0.15 mg/mL) fungi 0.0125–0.20 mg/mL). active biomolecules properties makes source health-promoting can be exploited novel herbal product.