Diphtheria Toxin-dependent Adenosine Diphosphate Ribosylation of Aminoacyl Transferase II and Inhibition of Protein Synthesis
作者： T Honjo , Y Nishizuka , O Hayaishi , I Kato
DOI: 10.1016/S0021-9258(18)93347-8
关键词:
摘要: In the presence of diphtheria toxin, adenosine diphosphate ribose portion nicotinamide adenine dinucleotide was transferred to aminoacyl transferase II obtained from rat liver. The reaction resulted in a concurrent inactivation this particular enzyme, one supernatant factors which assemble amino acids into polypeptide chain. linkage ADP-ribose appeared be covalent nature. reversible. Diptheria toxin may act as an enzyme or catalytic cofactor reaction.
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