The nanomechanical role of melanin granules in the retinal pigment epithelium.

摘要: Nanomechanical properties of cells and tissues, in particular their elasticity, play an important role different physiological pathological processes. Recently, we have demonstrated that melanin granules dramatically modify nanomechanical melanoma making them very stiff and, as a result, less aggressive. Although the mechanical effect was cells, it never studied case normal cells. In this work, analyzed impact on primary retinal pigment epithelium tissue fragments isolated from porcine eyes. The obtained results clearly show are responsible for exceptional tissue. Our findings suggest may sustaining stiffness single cell layer, which functions natural barrier separating retina choroid.