Radiation dose predicts for biochemical control in intermediate-risk prostate cancer patients treated with low-dose-rate brachytherapy.

摘要: Purpose: To evaluate the influence of patient- and treatment-related factors on freedom from biochemical failure (FFbF) in patients with intermediate-risk prostate cancer. Methods Materials: From a prospectively collected database 2250 men treated at Mount Sinai Hospital 1990 to 2004 low-dose-rate brachytherapy for cancer, 558 either one or more features (prostate-specific antigen [PSA] level 10-20 ng/mL, Gleason score 7, Stage T2b) were identified who had minimum follow-up 24 months postimplant CT-based dosimetric analysis. Biologically effective dose (BED) values calculated compare doses different isotopes treatment regimens. Patients without hormone therapy and/or external-beam radiotherapy. Patient- analyzed respect FFbF. The median was 60 (range, 24-167 months). Biochemical defined according Phoenix definition. Univariate analyses used determine whether any variable predictive A two-sided p value =}150 Gy{sub 2}) only significant predictor FFbF (p < 0.001). None other variables (PSA, radiotherapy,more » score, type, hormones, stage, number risk factors) found be statistically 10-year Conclusions: Radiation is an important Treatment should continue individualized presenting disease characteristics until results Therapy Oncology Group trial 0232 become available.« less